Manchester United striker Wayne Rooney will sit Wednesday's Champions League semi-final leg against Schalke 04 is a tight hamstring.
Holding 2-0 in the first leg and the crunch Premier League game against Chelsea in Sunday program, the installation of a boss Sir Alex Ferguson at his side.
Dimitar Berbatov is likely to begin before, possibly in collaboration with Michael Owen in attack on two fronts.
Fabio Da Silva will miss, but when he suffers a stroke.
The Brazilian took the injury on Sunday, defeating Arsenal 1-0 in a battle that assured the Prime Minister this weekend League match against Chelsea at Old Trafford could prove key in the title race this season.
United are three points ahead of the Blues with three games remaining in the season, but Sunday's defeat would be ahead at the top of the Premier League and playing catch up in their last two games of the season - Blackburn and Blackpool away in the home.
In this spirit, we believe that Ferguson remains a key number of the stars against the German Schalke on Wednesday.
The Red Devils beat Schalke in the first leg last week, the new 2-0.
And with Anders Lindegaard and Darren Fletcher available again after a knee injury and virus respectively liked the first election with Edwin van der Sar and Michael Carrick to sit the tie that the objective of the United States to reach 28 in May.
"Darren [Fletcher] is going to be part of the game," Ferguson said on Tuesday. "He has shown great improvement in the reserve game last week and his weight is back to normal.
"It's just a matter of time for play and a little stronger."
And speaking after the weekend defeat at Arsenal, the Scot said: "We have a great week ahead.
"Wednesday is a European semi-final second and ... Let's regroup and refresh. I will make some changes, no doubt. I'm going back to Paul Scholes, Dimitar Berbatov, Michael Owen.
"We're going to do, but I'll probably keep my experienced players on the back.
"We are in a position as good as you could ever wish the beginning of the season - semi-finals of the European Cup, the second stage, two-goal advantage into a home game in the difference [Sunday objectives and with an advantage] of three points. "
Ferguson was swift, but to warn against complacency on his side, adding: "We have to be favorites for the title, if only because we are three points ahead.
"But that can evaporate very quickly and have a big job to do. As I said last week, the drama is not over."
Schalke players themselves were forced to endure two hours late because of visa on Tuesday, before flying to England at Old Trafford tie.
Five of their players, such as the Peruvian Jefferson Farfán, Edu Brazil and Japan, Atsuta Uchida, had not given the relevant documents for non-EU passport holders.
The Germans expect to have Hoewedes Benedikt fit after a hamstring injury in the stomach, and Klass-Jan Huntelaar, after a period of two months due to a medial ligament injury of the knee.
Schalke boss Ralf Rangnick quarterfinal hopes his team's first stage victory on Inter Milan as they won 5-2, will inspire sufficient cons three times European champions at Old Trafford.
"In football, you have the opportunity, so we'll see what happens," he said. "When we played against Inter Milan, people do not give us much hope either.
"I think we should be well organized in the first 10 minutes, then we must take our chances when they are presented, but there are only two minutes.
"Do you think Manchester United and winning the Champions League, when he came back to win 2-1."
Manchester was comfortable from the first game in Germany and now they need to control the match and although he did not score to save two-goal lead.
I think Manchester think the final card of the Champions League and the yellow (and red, of course), because the poor to resolve the suspension will cost about the players in the game, and Alex Ferguson is preparing the players and tell them to slow down a great mistake.
On the other side Schalke even taking this into consideration, because if they do not advance to the European final of his next match could be in the 2012/13 season (they have little chance to win up to European Bundesliga).